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The world of growth hormone secretagogues has expanded rapidly in recent years, giving clinicians and patients a range of options for managing conditions such as growth hormone deficiency, lipodystrophy, and age-related wasting.
Among the most frequently discussed agents are
sermorelin, ipamorelin, and tesamorelin, each with distinct
pharmacological profiles, routes of administration,
and therapeutic indications. This discussion will
delve deeply into how these peptides compare, focusing specifically
on the relative effectiveness of tesamorelin versus CJC 1295 (also known as growth hormone-releasing
hormone analogue), while also providing a comprehensive introduction to the peptides themselves.
Introduction
Growth hormone secretagogues are short-acting peptides
that stimulate endogenous release of growth hormone (GH) by acting on the pituitary
gland. They differ from direct GH therapy in that they harness the body’s own regulatory
mechanisms, potentially reducing side effects
such as hyperglycemia and edema. Sermorelin is a synthetic
analogue of growth hormone-releasing hormone (GHRH) that mimics the natural pulse
of GH secretion. Ipamorelin is a selective ghrelin receptor agonist that stimulates
GH release with minimal impact on prolactin or cortisol.
Tesamorelin, meanwhile, is a recombinant GHRH analogue engineered for improved potency and longer duration of action;
it has received FDA approval specifically for reducing excess abdominal fat in HIV-associated lipodystrophy.
Overview of Tesamorelin and CJC 1295
Tesamorelin (also called ARA-290) is a 44-amino-acid peptide derived from GHRH.
It binds to the GH-releasing hormone receptor with high affinity, triggering intracellular signaling
that culminates in GH secretion. One of its key advantages is that
it does not cause an increase in insulin-like growth factor-1 (IGF-1) levels beyond the normal physiological range, thereby limiting potential oncogenic
or proliferative side effects. The drug is administered
subcutaneously once daily and has a half-life of approximately 30 minutes; however, because it stimulates endogenous GH
release in pulses, steady state concentrations are achieved after several weeks
of therapy.
CJC 1295 (also known as GHRH analogue 1) is another recombinant peptide
that shares structural similarities with tesamorelin but contains an additional lysine-lysine sequence
at its C-terminus. This modification confers a longer half-life, enabling
once-weekly or even once-monthly dosing in some formulations.
CJC 1295 is often used in combination with the
growth hormone secretagogue hexarelin to produce sustained GH release over several days.
The extended duration of action can be advantageous for patients who prefer less
frequent injections, but it may also lead to more pronounced side effects such
as edema or arthralgia if dosing is not carefully monitored.
Tesamorelin vs. CJC 1295: Which Is More Effective?
Efficacy in Reducing Visceral Fat
In clinical trials focused on HIV-associated lipodystrophy,
tesamorelin has consistently shown superior
efficacy in reducing abdominal visceral adipose tissue compared with
placebo or other interventions. The pivotal Phase III study demonstrated a mean reduction of 8–10%
in visceral fat volume after six months of daily therapy, accompanied by improvements in insulin sensitivity and lipid profiles.
CJC 1295, while capable of stimulating GH secretion, has not been evaluated in large-scale studies for this specific indication;
available data suggest modest reductions in body weight but less pronounced changes in visceral adiposity.
Duration and Sustainability of GH Stimulation
The transient nature of tesamorelin’s action allows for
a more physiological pattern of GH release. Peak concentrations
are achieved within 30–60 minutes after injection, followed by rapid
clearance. This pulsatile stimulation is thought to better
mimic natural circadian rhythms and may reduce the risk of desensitization at the pituitary level.
In contrast, CJC 1295’s prolonged presence in circulation can lead to a more
constant GH tone, which might blunt the normal negative feedback mechanisms and
potentially diminish responsiveness over time.
Side-Effect Profile
Both peptides are generally well tolerated, but their side-effect spectra differ subtly.
Tesamorelin is associated with mild injection site reactions and transient edema; serious adverse events are rare.
CJC 1295 can cause more pronounced fluid retention, arthralgia, and in some reports,
increased appetite leading to weight gain if not paired with a secretagogue
like hexarelin that mitigates this effect. The choice between the two
may hinge on patient tolerance for these side effects.
Dose-Response Relationship
Tesamorelin’s dose is fixed at 0.2 mg per injection; clinicians can adjust therapy based on response and IGF-1 levels.
CJC 1295, due to its longer half-life, often requires lower
daily or weekly doses (e.g., 1–3 µg/kg).
However, because of the variability in individual clearance rates, dose titration can be more complex, necessitating frequent monitoring of GH and IGF-1
levels to avoid supraphysiologic peaks.
Patient Compliance
Daily injections with tesamorelin may seem burdensome,
but the convenience of a once-daily regimen is offset by
its proven efficacy and lower risk of side effects. CJC 1295’s longer dosing interval (once weekly or
monthly) can enhance adherence for patients who
dislike frequent injections; yet this advantage must be weighed against potential safety concerns
if the peptide accumulates.
Clinical Indications
Tesamorelin has an FDA-approved indication specifically
for treating excess abdominal fat in HIV patients with lipodystrophy.
It is also used off-label for aging or sarcopenia, but such uses require careful monitoring of IGF-1 and
GH levels. CJC 1295 lacks a formal approval in the United
States; it is largely utilized in research settings or as an unapproved therapy in other countries.
Its broader application includes general growth hormone deficiency, bodybuilding, and anti-aging protocols, though data supporting
these uses are less robust.
Pharmacokinetics
The half-life of tesamorelin is approximately 30 minutes, but the pharmacodynamic effect lasts several hours due
to downstream GH release. CJC 1295’s extended half-life (up to 48–72 hours) results in a sustained pharmacologic stimulus that
can be advantageous for chronic conditions requiring steady GH levels.
However, this persistence may also increase the risk of rebound effects if
dosing is abruptly stopped.
Safety and Long-Term Outcomes
Long-term safety data for tesamorelin are favorable; large registries have not shown an increased incidence of
neoplasia or significant metabolic derangements after years of therapy.
CJC 1295’s long-term outcomes remain less defined, largely because most studies have been short-duration (3–6 months).
In the absence of comprehensive data, clinicians
often prefer tesamorelin for patients requiring prolonged GH stimulation.
Conclusion
When evaluating which agent is more effective, particularly for reducing
visceral adipose tissue and managing HIV-associated lipodystrophy, tesamorelin consistently outperforms CJC 1295 in both clinical trials and real-world
practice. Its daily dosing regimen delivers a physiologic pattern of GH release with minimal side effects, while its efficacy has been rigorously demonstrated.
CJC 1295 offers the convenience of less frequent injections
but carries a higher potential for fluid retention, joint pain, and uncertain long-term safety data.
Ultimately, the choice between tesamorelin and CJC 1295 should be guided by the specific clinical indication, patient preferences regarding dosing
frequency, tolerance for side effects, and evidence-based efficacy.
Sermorelin and Ipamorelin
While tesamorelin and CJC 1295 dominate discussions
about GHRH analogues, sermorelin and ipamorelin are also significant
players in the secretagogue landscape. Sermorelin is a truncated form of natural GHRH that stimulates GH release
but does so with a lower potency than tesamorelin; it is often used
for diagnosing growth hormone deficiency rather than long-term therapy.
Ipamorelin, a selective ghrelin receptor agonist, uniquely increases GH
without affecting prolactin or cortisol and can be combined with other secretagogues to enhance
the overall hormonal response.
In summary, all four peptides—sermorelin, ipamorelin, tesamorelin, and CJC 1295—offer distinct
mechanisms of action, dosing schedules, and
clinical benefits. For patients seeking robust, evidence-based reduction in visceral fat with
a favorable safety profile, tesamorelin remains the gold standard; CJC 1295 may be reserved for
cases where less frequent injections are paramount, provided that careful monitoring is undertaken. Sermorelin and ipamorelin serve complementary roles
in diagnostics and adjunctive therapy, respectively, enriching
the therapeutic toolbox available to endocrinologists and clinicians
managing growth hormone-related disorders.
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With such medical presentations, elevated bilirubin values are additionally to be anticipated.
Other stories in literature have additionally documented peliosis hepatis
(102, 103), hepatocellular carcinoma (104) and adenoma (105, 106) in association with AAS use.
The incidence is probably (very) low and a firm causal hyperlink has not been established.
“Steroids” is an umbrella time period that can be utilized to
discuss with corticosteroids, anabolic steroids, and intercourse hormone steroids.
“We have to coach folks,” says Thomas O’Connor, aka the
“Anabolic Doc,” who focuses on sufferers in search of restoration from anabolic-steroid use.
O’Connor doesn’t advocate using any of these medication and has dozens of horror tales from sufferers to assist his position—including, in excessive instances, dying.
Deca and Dianabol regimen Fakhri Mubarak, a
prep coach who speaks brazenly about his personal steroid use, strongly recommends discovering a
health skilled you’ll have the ability to work with when you do
select to make use of efficiency enhancers.
Alright this isn’t a Complement, I know I’m dishonest, however cardio is free!
Cardio can do everything, decrease blood pressure, lower ldl
cholesterol, enhance insulin sensitivity, scale back irritation,
and (from personal experience) helps your breath better!
Better respiratory means higher sleep which… nah you know how necessary that’s
(hopefully).
Different forms of steroids include estrogen and progesterone, which are utilized
in hormone substitute therapy, and corticosteroid
creams, that are used to treat pores and skin situations.
But not like males who will achieve little muscle with these “milder” steroids, women will find that these are more than highly effective sufficient to promote good muscle positive aspects, together with fat loss
and performance benefits. Dianabol-only cycle is a standard
beginner selection because, as an oral compound, it’s easy to take and helps
you keep away from injecting. You’ll solely be doing a 6-week cycle on Dianabol to keep away from liver toxicity.
Dbol can even increase levels of estrogen as a outcome of it
could aromatize, which brings some potential unwanted side effects like gynecomastia (increased breast tissue) and fluid retention. You may also must
watch out for androgenic unwanted effects and think about taking aromatase inhibitor medicine alongside it to
scale back estrogen and decrease these side effects.
Anabolic refers to development promotion, whereas androgenic refers again to
the improvement of male intercourse characteristics. They make you susceptible cancers of the liver and hepatitis The unwanted effects can result in demise.
When a quantity of doses of those medication are administered over a particular period of time, adopted by an interval,
and re-started once more it’s known as ‘cycling’.
Nevertheless, solely two-thirds of subjects had been azoo- or oligozoospermic on the finish of their cycle (176).
There was no association between the duration of the AAS
cycle and the diploma of suppression of spermatogenesis.
Testosterone is bioactivated into a stronger
androgen in tissues expressing enzymes of the 5α-reductase family.
These enzymes catalyze a reduction response at carbon 5, adding an α-oriented hydrogen atom.
With testosterone as a substrate, this response yields essentially the
most potent naturally occurring androgen, namely, dihydrotestosterone (DHT).
In adults these enzymes are expressed, among other tissues, within the
liver, pores and skin, prostate, epididymis, seminal vesicles, testis, kidney, pancreas and brain (19).
It ought to be noted that DHT isn’t thought to contribute to
the muscle-building effects of testosterone.
Nevertheless, it might possibly still pose liver toxicity and negatively impact cholesterol levels,
demanding accountable usage. Dromostanolone is a synthetic anabolic steroid with anti-estrogenic properties
and is 5 occasions more potent than methyltestosterone, which is
usually used illegally by bodybuilders to arrange for competition. Abuse of anabolic steroids, however, can result
in significant harm to the body.
Because of this, they tend to be used more by
severe bodybuilders and athletes who’ve coaches and medical staff around them to help with administration. This
is as a outcome of oral AAS drugs have to be processed by the digestive tract first, they
don’t act as quick as injectable options
do. Nevertheless, given the nature of the drugs and what they are meant
to accomplish, this isn’t a big concern.
Without the rigorous testing and compliance course of that comes with permitted pharmaceuticals, no official shelf life for any SARM exists.
This means we must use common sense concerning storage and estimated shelf life, very like you do with meals.
While you’re not likely to fall unwell should you use SARMs exterior their shelf
life, they can probably be less efficient over time as they lose their potency.
Ostarine ensures that joint and muscle pain is decreased or
eradicated, and Ostarine may help cut back irritation.
Hair loss is more doubtless to accelerate as a end result of DHT ranges spiraling to high ranges, causing inflammation and
harm to hair follicle health. Difficulty urinating may also become a problem because of an enlarged prostate gland.
Additionally, trenbolone just isn’t estrogenic
(failing to aromatize), making it a dry compound and
thus a very desirable slicing agent. Trenbolone is
arguably essentially the most powerful steroid out there to bodybuilders, causing fast modifications in physique composition that take
place inside the first week of use.
Bodybuilders use it during bulking cycles for noticeable size gains in weeks.
While it delivers impressive results, understanding both benefits and dangers is essential.
All The Time seek the assistance of a healthcare provider before contemplating any steroid use.
The identical beta2-adrenergic receptors that activate when taking clenbuterol for asthma
also help enhance lean muscle mass whereas decreasing body
fat. As A End Result Of of such results, clenbuterol is typically seen as an various to anabolic steroids — the medication that sometimes come to thoughts when you consider performance-enhancing substances.
An undetermined percentage of anabolic steroid customers could develop a anabolic steroid use dysfunction. Anabolic steroid users additionally
may surrender other necessary actions for fear that they’ll miss workouts, violate their dietary restrictions, or be prevented
from utilizing anabolic steroids.
This is probably not a complete list of medicines that may work together with oxandrolone.
Tell your health care supplier if you’re breastfeeding
or plan to breastfeed. Your well being care supplier will let you know if you
should cease breastfeeding or cease oxandrolone. Tell your well being care supplier
in case you are pregnant or plan to turn out to be pregnant.
If you turn into pregnant, stop taking oxandrolone instantly and get in contact with your
health care supplier.
Due To This Fact, for cutting cycles, select
steroids which most actively have an result on the breakdown of adipose tissue
and don’t have any aromatization. There aren’t any finest steroids for
weight reduction, as all AAS will cause weight acquire. We usually see testosterone inflicting only delicate fluctuations
in ldl cholesterol when taken in modest dosages with little
hepatic toxicity. Thus, it is certainly one of the most cardiovascular-friendly anabolic steroids out
there.
Throughout any cycle you’ll hit a wall and the positive aspects will sluggish
or come to a screeching halt. Introducing Dianabol during this phase will see you break via the
plateau or sticking point, and your progress will proceed.
Due to the hepatotoxicity of Dbol, and as a result of the fact
that most cycles will fall in the 8-12 week vary, most will only use Dianabol for one of those purposes throughout a
single cycle. However, in hardcore bodybuilding
cycles that often prolong nicely previous the 12 week mark, it will be possible
to implement each phases of use with necessary C17-aa breaks.
Regardless of the type of use, dose or timing schedule you utilize, you
will find Dianabol stacks well with all anabolic steroids.
Healthcare suppliers prescribe them for certain conditions, such as male hypogonadism and certain forms of breast most cancers.
Turinabol is often taken for 6–8 weeks, which is a considerably lengthy oral cycle as a result of its longer ester
construction and slow-acting properties. If a Turinabol-only cycle is being carried out, just
one SERM could additionally be needed post-cycle.
Nevertheless, if Turinabol is stacked with other suppressive anabolics, two SERMs may be taken synchronously.
To cut back the risk of hypertension on Turinabol, we have discovered
common cardio and supplementation with four grams of fish oil per day, for the
period of a cycle, to be effective.
Nevertheless, individuals who genetically reply well to Anadrol
can expertise increased well-being due to the massive enhance in testosterone.
Due to Anadrol causing noticeable quantities of extracellular fluid retention,
it’s not essentially the most optimal steroid for vascularity.
It has been theorized that these estrogenic unwanted aspect effects are due to Anadrol acting as a progestin; however, research present
Anadrol to have little impact on progesterone levels.
Nosebleeds and headaches can occur while on Anadrol, which can be
a sign of elevated blood stress. If this occurs, get
a checkup, and if your blood strain is high, cycle off immediately.
This means most suppressive effects will probably come from other AAS getting used.
A maximum dosage of 100mg/day is commonly considered
by advanced users of Winstrol, particularly for an upcoming competitors.
In this case, an advanced Winstrol cycle might contain using 50mg/day for four
weeks, rising to 100mg/day for the final two weeks of
this 6 to 8-week cycle. Regardless of expertise level, the utmost size of a Winstrol cycle is
beneficial to be not than eight weeks because of the impacts in your cholesterol and liver.
Decreased intercourse drive is a matter for some ladies on Winny, and a few have
complained about some fairly severe temper and mental issues developing – again, these are individual responses.
Females who discover an initial voice change after
rising the dose by simply 1mg or 2mg will typically decrease the dosage to get rid of the virilizing risk.
When we measure Winstrol’s results, it’s hardly
ever within the quantity of muscle gained or fat misplaced.
Maintain all appointments together with your well being care provider to examine your blood.
Name your well being care provider when you have the following signs of high blood
sugar. The above dosages are generally taken by intermediate steroid users.
Later, in 1929 a procedure to produce an extract of potent activity from bull’s testicles was attempted, and
in 1935 a extra purified type of this extract was created.
A year later, a scientist named Ruzicka synthesized this compound,
testosterone, from cholesterol, as did two other scientists,
Butenandt and Hanisch (3). Testosterone was, of course, the first
anabolic steroid ever created, and stays the idea for all different derivations we now have presently being utilized in medication right now.
(4) Shortly after this time, the Nazi´s have been rumored to
have given their soldiers anabolic steroids, however that rumor appears to
be largely undocumented. Later, additional experiments had been carried out in men,
in fact exhibiting that testosterone was a potent anabolic substance in humans.
It’s true that using sure steroids in small amounts
underneath medical supervision won’t harm you.
However, using massive quantities of anabolic steroids for
an extended period of time can do you real hurt. The medicine are artificially derived from the hormone testosterone.
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In addition, research has demonstrated a constructive effect on therapeutic from muscle contusion injuries (Beiner et al., 1999).
AASs exert their results by activating androgen receptor (AR) signaling.
A Number Of elements of the body are involved
due to the presence of ARs in many tissues [12].
GnRH binds to its receptor, the GnRH receptor, on gonadotrophic cells
of the anterior pituitary. Activating this G protein-coupled receptor triggers a cascade of events that stimulates the synthesis and launch
of luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
LH and FSH, in turn, bind to their cognate receptors on the
Leydig cells and Sertoli cells of the testis,
respectively. LH stimulates testosterone manufacturing and, along side FSH, regulates spermatogenesis.
Outdoors of medicine, each women and men use steroids to improve athletic
performance and alter physical appearance by growing muscle mass and reducing physique fat.
Throughout the Sixties and 1970s, as bodybuilding began to gain popularity, Primobolan caught the attention of athletes looking to improve
their efficiency. Its popularity for helping retain muscle mass while promoting fat loss made it a favored choice for bodybuilders preparing for competitions.
Notably, Primobolan was lauded for its decrease threat of androgenic unwanted side
effects in comparability with other steroids, permitting both women and men to use it with fewer
considerations about negative effects. Understanding the unwanted facet effects of steroids is crucial for
athletes and bodybuilders.
Anabolic-androgenic steroids (AASs) have many different potential medical
makes use of. In most clinical eventualities, the association of protein-calorie
malnutrition increases the morbidity and mortality of the primary illness state.
By preventing this loss of lean physique mass, the clinician can hope
to stop many of the opposed effects caused by the illness and, maybe,
by other therapies which have been enacted.
In all medical cases, excluding cancer, AASs have proven efficacy in weight achieve.
One Other methodology referred to as “stacking” involves taking more than one
type of anabolic steroid at a time in hopes that it will make
the medicine work better. Medical Doctors prescribe corticosteroids far
more usually than anabolic steroids. You may have them to treat conditions such as asthma,
eczema, muscle and joint circumstances, lupus, or multiple sclerosis.
The greatest advice I can provide is to stay natty as long as you presumably
can, build yourself a good pure base physique so you then don’t ALWAYS
have to depend on gear to look good. If I may do it once more I’d wait to do my 1st cycle until 26 yrs old or older should you can maintain out.
You’ll most likely be near their size at age 26 and then u’ll do ur 1st cycle
and ur gna make them look anorexic by the point ur cycle is over.
Hence, this write-up is an try and encapsulate many
of the essential info in phrases of anabolic steroids. However sadly,
thousands of fitness center lovers knowingly
and unknowingly have been using these anabolic steroids.
Energy can refer to power and pace, both key components to successful athleticism.
Nonetheless, where this steroid will truly be useful is within the promotion of restoration.
The prevalence of maximum circumstances of violence amongst those who use steroids appears to be low,
however as with the health results, extreme violence could be underreported or underrecognized.
Orals, for instance, come with that well-known danger to the liver, so it’s out of the query to use them longer.
Blood pressure and ldl cholesterol increases are some of the other
vital risk factors for normal and high-dose steroid use.
Some steroids are stronger in this effect than others, however all males might want to
deal with this aspect effect no matter which compound
is getting used. You can solely inject smaller amounts of liquid by
way of this technique, in distinction to the larger amount of steroids that could
be injected intramuscularly. It’s important to bear
in mind that it’s not normal for blood to look when you’re
injecting steroids into the muscle. If there’s any blood if you insert the needle, you
hit a vein or artery somewhat than simply muscle tissue.
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